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Updated: Oct 12, 2026

Polygraphic Recording Procedure for Measuring Sleep in Mice
Published on: January 25, 2016
The relevance of pharmacological studies to sleep research in psychiatry
1Janssen Pharmaceutica N.V., Beerse, Belgium.
Abstract:
The involvement of central serotonergic mechanisms in the organisation of human sleep has been confirmed in several single and multiple-dose clinico-pharmacological studies with the specific serotonin-S2-antagonist ritanserin. The pronounced thymosthenic effect observed with this compound in patients suffering from dysthymia, generalized anxiety disorder and negative symptoms of schizophrenia can possibly be attributed to a restoration of the energetic function during the night as a consequence of a dramatic increase in slow wave sleep during treatment with ritanserin.
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