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MicroRNAs as modulators of longevity and the aging process.
Holly E Kinser1, Zachary Pincus2
1Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, USA.
Human Genetics
|July 13, 2019
Summary
MicroRNAs (miRNAs) are small RNAs regulating aging. They act as biomarkers and influence longevity and age-related diseases in various tissues.
Area of Science:
- Molecular Biology
- Genetics
- Gerontology
Background:
- MicroRNAs (miRNAs) are short, non-coding RNAs regulating gene expression post-transcriptionally.
- miRNAs are involved in diverse biological pathways, including the aging process.
- Differential expression of miRNAs during aging suggests their role as biomarkers and regulators.
Purpose of the Study:
- To review the role of miRNAs in aging and longevity.
- To highlight miRNAs as potential biomarkers for aging.
- To discuss miRNA regulation of age-associated processes and pathologies in mammalian tissues.
Main Methods:
- Literature review of studies on miRNAs and aging.
- Analysis of findings in model organisms (C. elegans, Drosophila) and mammals.
- Focus on individual miRNA roles in longevity and tissue-specific aging.
Main Results:
- miRNAs modulate longevity positively and negatively in invertebrates.
- miRNAs are differentially expressed during aging across various mammalian tissues (brain, heart, bone, muscle).
- Individual miRNAs are implicated as regulators of age-associated processes and pathologies.
Conclusions:
- miRNAs are key regulators of aging and longevity.
- miRNAs show potential as biomarkers for aging.
- Further research into miRNA function can inform strategies for age-related diseases.
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