Related Experiment Video
Updated: Jan 22, 2026

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
Published on: November 17, 2015
Effect of Doxycycline-Loaded Solid Lipid Nanoparticles on Serum Level of Trace Elements, Biochemical and
Seyed Mostafa Hosseini1, Abbas Farmany2, Mohammad Reza Arabestani3,4
1Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Abstract:
Disease relapse is one of the most important challenges in treating brucellosis. The aim of this study was to investigate the effect of doxycycline-loaded solid nanoparticles (DOX-SLN) on acute and chronic brucellosis, serum levels of trace elements, and biochemical and hematological parameters in rats infected with Brucella melitensis. The treating effect of DOX-SLN was evaluated by investigating serum levels of trace elements such as zinc (Zn), copper (Cu), iron (Fe), magnesium (Mg), calcium (Ca), phosphorus (P), sodium (Na), and potassium (K); biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin (TBil); and hematological parameters in rats suffering from acute and chronic brucellosis. The mean size, zeta potential, PDI, drug loading, and encapsulation efficiency of the synthesized nanoparticles were 299 ± 34 nm, - 28.7 ± 3.2 mV, 0.29 ± 0.027, 11.2 ± 1.3%, and 94.9 ± 3.2%, respectively. The serum level of trace elements (Zn, Cu, Fe), biochemical parameters (AST, ALT, ALP, TBil), and hematological parameters (white blood cell (WBC) and hemoglobin (HB)) were significantly different between healthy and infected rats. DOX-SLN had an appropriate treating effect on chronic brucellosis through modifying the serum level of mentioned factors. Assessing the serum level of trace elements, biochemical and hematological parameters can be useful in detecting brucellosis with other diagnostic tests and determining its acute or chronic phase. DOX-SLN had a better efficacy in treating chronic brucellosis than ordinary free drugs used routinely in this regard.
Related Concept Videos
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
Key Elements for Plant Nutrition
Periodic Classification of the Elements
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Elements and Compounds
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
The Periodic Table and Organismal Elements

