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Updated: Jan 22, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
08:59

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

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Long non-coding RNA HOTAIR/microRNA-206 sponge regulates STC2 and further influences cell biological functions in

Tiancheng Li1, Yao Qin1, Zhen Zhen1

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Peking University First Hospital, Beijing, China.

Cell Proliferation
|July 13, 2019
PubMed
Abstract

Insights

Homeobox transcript antisense RNA (HOTAIR) promotes head and neck squamous cell carcinoma (HNSCC) progression by sponging microRNA-206 (miR-206) to upregulate stanniocalcin-2 (STC2). Inhibiting HOTAIR or boosting miR-206 hinders HNSCC growth.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • Head and neck squamous cell carcinoma (HNSCC) is a prevalent cancer requiring novel therapeutic targets.
  • Understanding the molecular mechanisms driving HNSCC is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the role of homeobox transcript antisense RNA (HOTAIR) in HNSCC.
  • To elucidate the regulatory axis involving HOTAIR, microRNA-206 (miR-206), and stanniocalcin-2 (STC2) in HNSCC.
  • To identify potential therapeutic targets for HNSCC treatment.

Main Methods:

  • Differential gene expression analysis and network construction to identify the HOTAIR/miR-206/STC2 regulatory network.
  • In vitro experiments involving HOTAIR overexpression and knockdown to assess effects on HNSCC cell functions (proliferation, invasion, migration).
  • In vivo tumor growth assays in nude mice to evaluate the therapeutic potential of targeting the HOTAIR/miR-206/STC2 axis.

Main Results:

  • HOTAIR was found to directly bind to miR-206, which in turn targets STC2.
  • Downregulation of HOTAIR or upregulation of miR-206 significantly inhibited HNSCC cell proliferation, invasion, and migration.
  • miR-206 suppressed the PI3K/AKT signaling pathway by downregulating STC2.
  • Silencing HOTAIR or overexpressing miR-206 repressed HNSCC tumor growth in vivo.

Conclusions:

  • HOTAIR plays a critical role in regulating HNSCC cell biological functions.
  • The HOTAIR/miR-206/STC2 axis represents a significant molecular pathway in HNSCC.
  • Targeting this axis holds promise for HNSCC therapeutic strategies.
Keywords:
head and neck squamous cell carcinomainvasionlong non-coding RNA homeobox transcript antisense RNAmicroRNA-206migrationproliferationstanniocalcin-2

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