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Updated: Jan 22, 2026

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
Published on: October 19, 2015
Simulation of the long-term fate of superparamagnetic iron oxide-based nanoparticles using simulated biological
Martin Rabel1, Paul Warncke1, Cordula Grüttner2
1Pharmaceutical Technology & Biopharmacy, Friedrich Schiller University Jena, Lessingstraße 8, 07743 Jena, Germany.
Abstract:
Aim: To simulate the stability and degradation of superparamagnetic iron oxide nanoparticles (MNP) in vitro as part of their life cycle using complex simulated biological fluids. Materials & methods: A set of 13 MNP with different polymeric or inorganic shell materials was synthesized and characterized regarding stability and degradation of core and shell in simulated biological fluids. Results: All MNP formulations showed excellent stability during storage and in simulated body fluid. In endosomal/lysosomal media the degradation behavior depended on shell characteristics (e.g., charge, acid-base character) and temperature enabling the development of an accelerated stress test protocol. Conclusion: Kinetics of transformations depending on the MNP type could be established to define structure-activity relationships as prediction model for rational particle design.
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