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Gut Microbiota, Obesity and Bariatric Surgery: Current Knowledge and Future Perspectives
Adriana Florinela Cӑtoi1, Dan Cristian Vodnar2, Andreea Corina3,4
1Pathophysiology Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Current Pharmaceutical Design
|July 13, 2019
Summary
Modulating the gut microbiome shows promise for treating obesity and related diseases. Further research into microbiota modulation could lead to personalized therapies and new drug discoveries for obesity management.
Area of Science:
- Microbiome research
- Obesity and metabolic disease
Background:
- Obesity is linked to structural and functional alterations in the gut microbiome.
- There is a critical need to understand and manage obesity and its associated diseases.
Purpose of the Study:
- To review current evidence on microbiota modulation for obesity and metabolic dysfunction.
- To explore the effects and potential efficacy of interventions targeting the gut microbiome.
Main Methods:
- Review of animal and human studies.
- Analysis of mechanisms linking gut microbiota dysbiosis and obesity.
- Discussion of bariatric surgery as a model for understanding metabolic effects and microbiota changes.
Main Results:
- Gut microbiota dysbiosis has a dual interaction with obesity.
- Bariatric surgery favorably impacts metabolic and inflammatory effects, altering gut microbiota composition.
- Anti-obesity and novel antidiabetic drugs may influence the gut microbiota.
Conclusions:
- More research is needed to fully understand the association between microbiota modulation and obesity.
- Future research may enable personalized therapeutic approaches based on individual microbiomes.
- This field holds potential for discovering new drugs and combination therapies for obesity management.
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