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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.6K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

5.1K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
5.1K
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

2.1K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
2.1K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.6K
Overview of Muscle Tissues01:25

Overview of Muscle Tissues

21.5K
The human body has three types of muscle tissue: skeletal, smooth, and cardiac. Each class has unique properties that enable them to perform specific functions. However, all muscle tissues share certain properties, including elasticity, contractility, and excitability. 
Elasticity
Elasticity is the ability of muscles to stretch and return to their original shape. This property is partly due to elastic fibers — macromolecules that run through the muscles. These fibers are firm and...
21.5K
Adult Stem Cells01:33

Adult Stem Cells

33.4K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.4K

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Use of Human Perivascular Stem Cells for Bone Regeneration
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Use of Human Perivascular Stem Cells for Bone Regeneration

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An Overview on Stem Cells in Tissue Regeneration.

Rajasekar Seetharaman1, Anjum Mahmood1, Prashant Kshatriya1

  • 1GIOSTAR Research Pvt.Ltd, Ahmedabad, Gujarat, India.

Current Pharmaceutical Design
|July 13, 2019
PubMed
Summary

Regenerative medicine uses stem cell therapy to repair damaged tissues and organs, offering new hope for treating diseases previously incurable by conventional methods. This approach leverages stem cells' self-renewal and differentiation capabilities for improved patient outcomes.

Keywords:
Stem cellscell therapychronic diseasesmesenchymal stem cellsregenerative medicinetissue regeneration.

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Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Tissue Engineering

Background:

  • Tissue and organ function decline due to aging, disease, or injury significantly impacts quality of life.
  • Regenerative medicine aims to restore function by replacing or repairing impaired cells, tissues, and organs.
  • Current regenerative approaches include biomolecules, stem cell transplants, tissue engineering, gene therapy, and cell reprogramming.

Purpose of the Study:

  • To review recent advancements in tissue regeneration.
  • To highlight the application of stem cell transplants in treating life-threatening diseases.
  • To discuss the potential of stem cell-based therapies for improving quality of life.

Main Methods:

  • Review of preclinical and clinical applications of stem cells.
  • Analysis of stem cell characteristics, including self-renewal and differentiation potential.
  • Exploration of various stem cell types (e.g., mesenchymal, embryonic, induced pluripotent).

Main Results:

  • Stem cell research has advanced cell-based therapies as viable treatment options for previously incurable diseases.
  • Stem cells possess unique self-renewal and differentiation capabilities crucial for regenerative medicine.
  • Numerous reports confirm the vital role of stem cells in disease management.

Conclusions:

  • Stem cell therapy represents a promising frontier in treating a wide range of conditions.
  • Ongoing research and development are focused on creating effective stem cell-based products.
  • The potential of stem cells to revolutionize healthcare is substantial, offering new therapeutic avenues.