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New findings of heparanase in human diseases

H Jin1, M Cui, S-X Hu

  • 1The Second Department of General Surgery, Zhuhai People's Hospital, Xiangzhou District, Zhuhai City, Guangdong Province, China. jh199003240014@126.com.

European Review for Medical and Pharmacological Sciences
|July 13, 2019
PubMed

Insights

Heparanase is implicated in various diseases beyond cancer, including inflammation and preeclampsia. Targeting heparanase offers a promising therapeutic strategy for these conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pathology

Background:

  • Heparanase is an enzyme involved in extracellular matrix degradation.
  • Its role in tumor progression is well-established.
  • Recent research has uncovered additional pathological functions.

Purpose of the Study:

  • To review recent research on heparanase functions and inhibitors (2017-2018).
  • To explore heparanase as a therapeutic target for various diseases.

Main Methods:

  • Literature search in PubMed, Web of Science, and CNKI databases.
  • Keywords: heparanase, function, diseases, inhibitors.
  • Hand-search for peer-reviewed articles and reports.

Main Results:

  • Heparanase activity is linked to tumor progression.
  • New associations found with procoagulant activities, preeclamptic placentas, and inflammation.
  • These functions correlate with cellular processes like epithelial to mesenchymal transition (EMT).

Conclusions:

  • Heparanase plays a role in diverse pathological processes.
  • Heparanase represents a valuable and potential therapeutic target.
Abstract

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