Related Experiment Video

Updated: Jan 22, 2026

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
08:52

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

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Systematic review and network meta-analysis of first-line therapy for advanced EGFR-positive non-small-cell lung

Jacob Franek1, Joseph C Cappelleri2, Kelly A Larkin-Kaiser1

  • 1Medlior Health Outcomes Research Ltd, Calgary, Alberta, T2C 5P9, Canada.

Future Oncology (London, England)
|July 13, 2019
PubMed

Insights

Dacomitinib and osimertinib show improved clinical efficacy for advanced EGFR-positive non-small-cell lung cancer (NSCLC) compared to other first-line EGFR tyrosine kinase inhibitors (TKIs). These findings support their use as standard treatments.

Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Trials

Background:

  • Advanced non-small-cell lung cancer (NSCLC) with EGFR mutations presents a therapeutic challenge.
  • Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are a key treatment modality for EGFR-positive NSCLC.

Purpose of the Study:

  • To compare the relative clinical efficacy of first-line EGFR-targeted tyrosine kinase inhibitors (TKIs) in patients with advanced EGFR-positive NSCLC.
  • To identify superior TKI options for first-line treatment based on survival outcomes.

Main Methods:

  • Systematic literature search of 11 electronic databases (January 2004 - August 2018).
  • Inclusion of randomized controlled trials (RCTs) evaluating first-line TKI therapies.
  • Bayesian network meta-analysis to assess overall survival (OS) and progression-free survival (PFS).

Main Results:

  • Dacomitinib and osimertinib demonstrated improved efficacy outcomes compared to afatinib, erlotinib, and gefitinib.
  • Both dacomitinib and osimertinib showed superior overall survival and progression-free survival benefits.
  • The meta-analysis provides a quantitative comparison of first-line EGFR TKIs.

Conclusions:

  • Dacomitinib and osimertinib are recommended as standard first-line treatment options for advanced EGFR-positive NSCLC.
  • These findings guide clinical decision-making for optimizing patient outcomes.
  • Further research may explore long-term efficacy and safety profiles.
Keywords:
epidermal growth factor receptor positivenetwork meta-analysisnon-small-cell lung canceroverall survivalprogression-free survivaltyrosine kinase inhibitors

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