Related Experiment Video
Updated: Jan 22, 2026

06:41
Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
Published on: May 19, 2023
2.5K
Short-Term Disability Fluctuations in Late Life
Erwin Stolz1, Thomas M Gill2, Hannes Mayerl1
1Institute of Social Medicine and Epidemiology, Medical University of Graz, Austria.
Summary
Late-life disability fluctuates significantly, with short-term changes linked to mortality and increasing disability. These fluctuations, averaging one limitation, highlight dynamic changes in later life.
Area of Science:
- Gerontology
- Public Health
- Biostatistics
Background:
- Late-life disability is recognized as dynamic, but short-term, within-person fluctuations have not been previously quantified.
- Understanding these fluctuations is crucial for assessing the trajectory of aging and its associated health outcomes.
Purpose of the Study:
- To quantify the magnitude of short-term disability fluctuations in late life.
- To investigate the association of these fluctuations with time-to-death, long-term disability trajectories, frailty, and sociodemographic factors.
Main Methods:
- Analysis of monthly survey data on activities of daily living/instrumental activities of daily living (ADL/IADL) disability from 642 deceased individuals (Precipitating Events Project Study).
- A two-step statistical approach using Poisson and linear mixed regression models to identify and analyze observation-level residuals representing short-term disability fluctuations.
Main Results:
- Short-term disability fluctuations averaged approximately one ADL/IADL limitation.
- These fluctuations increased in the final four years of life and were strongly associated with overall disability increases.
- No significant associations were found with frailty or most sociodemographic characteristics, except for living alone.
Conclusions:
- Substantial short-term disability fluctuations occur in late life.
- These fluctuations are linked to mortality-related processes and accompany the general increase in disability towards the end of life.
Related Concept Videos
Half-life of a Reaction
38.8K
The half-life of a reaction (t1/2) is the time required for one-half of a given amount of reactant to be consumed. In each succeeding half-life, half of the remaining concentration of the reactant is consumed. For example, during the decomposition of hydrogen peroxide, during the first half-life (from 0.00 hours to 6.00 hours), the concentration of H2O2 decreases from 1.000 M to 0.500 M. During the second half-life (from 6.00 hours to 12.00 hours), the concentration decreases from 0.500 M to...
38.8K
Characteristics of Life
257.0K
Biology is a natural science that studies life and living organisms, including their structure, function, development, interactions, evolution, distribution, and taxonomy. The field's scope is extensive and divided into several specialized disciplines, such as anatomy, physiology, ethology, genetics, and many more. All living things share a few key traits, including cellular organization, heritable genetic material and the ability to adapt/evolve, metabolism to regulate energy needs, the...
257.0K
Intellectual Disability
680
Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
680
Learning Disabilities
580
Learning disabilities are cognitive disorders caused by neurological impairments that affect cognitive functions like language and reading, without indicating overall intellectual or developmental challenges. These disabilities differ from global intellectual or developmental disabilities as they are limited to distinct cognitive functions. Common learning disabilities include dysgraphia, dyslexia, and dyscalculia, each of which impacts unique aspects of learning.
Dyslexia
Dyslexia is a...
Dyslexia
Dyslexia is a...
580
The Tree of Life - Bacteria, Archaea, Eukaryotes
38.0K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
38.0K
The Angiosperm Life Cycle
72.2K
Plants have a life cycle split between two multicellular stages: a haploid stage—with cells containing one set of chromosomes—and a diploid stage—with cells containing two sets of chromosomes. The haploid stage is the gamete-producing gametophyte, and the diploid stage is the spore-producing sporophyte.
72.2K

