Antimetastatic Properties of Tea Polyphenols

Metastasis of cells from primary site to distant organs involves a series of sequential steps, and molecules responsible for all these events are understandably considered as potential targets for metastasis management. Tea polyphenols, the secondary metabolites of the tea leaf Camellia sinensis, are increasingly being studied for their antimetastatic properties. In this article, effects of green tea polyphenols (GTP) and black tea polyphenols (BTP) on the molecules and events involved in metastasis are discussed in detail. As tea is a very popular beverage, tea polyphenols are expected to be potential chemopreventive agents that can be taken with normal diet and can be nontoxic due to their natural origin. However, individual variations in metabolic pathways, bioavailability, dose, and toxicity are some important factors that can modify the effectiveness of tea polyphenols within the human system.