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Related Experiment Video

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Concurrent EEG and Functional MRI Recording and Integration Analysis for Dynamic Cortical Activity Imaging
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Thalamic low frequency activity facilitates resting-state cortical interhemispheric MRI functional connectivity.

Xunda Wang1, Alex T L Leong1, Russell W Chan2

  • 1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China; Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China.

Neuroimage
|July 13, 2019
PubMed
Summary

Low frequency activity in the thalamus drives brain-wide functional connectivity observed in resting-state functional MRI (rsfMRI). This highlights the thalamus

Keywords:
Cortical layersOptogeneticResting-state MRI functional connectivityThalamusfMRI

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Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Functional Neuroimaging

Background:

  • Resting-state functional MRI (rsfMRI) maps brain networks but its neural basis is unclear.
  • The thalamus, a key relay, influences cortical integration, yet its role in rsfMRI connectivity is understudied.

Purpose of the Study:

  • To investigate the somatosensory thalamus' contribution to interhemispheric rsfMRI connectivity.
  • To elucidate the neural mechanisms underlying rsfMRI connectivity.

Main Methods:

  • Multi-modal approach combining rsfMRI, optogenetic stimulation, and multi-depth cortical electrophysiology.
  • Examined the effects of stimulating and inhibiting VPM thalamocortical neurons on rsfMRI connectivity and neural oscillations.

Main Results:

  • Optogenetic stimulation of VPM neurons increased interhemispheric rsfMRI connectivity and infraslow BOLD activity in sensory cortices.
  • Inhibition of VPM neurons decreased interhemispheric rsfMRI connectivity and infraslow BOLD activity.
  • Low-frequency neural oscillations (<10 Hz) in the thalamocortical network correlated with rsfMRI connectivity.

Conclusions:

  • Low-frequency thalamic activity is a critical driver of brain-wide rsfMRI connectivity.
  • The thalamus plays a pivotal role in establishing and modulating long-range functional connections detected by rsfMRI.