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Related Experiment Video

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Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Published on: September 27, 2013

Biodegradable micro-sized discoidal polymeric particles for lung-targeted delivery system.

Jun Young Park¹, Sanghyo Park², Tae Sup Lee³

¹Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.

|July 13, 2019

Summary

Micro-sized discoidal polymeric particles (DPPs) show promise for lung-targeted drug delivery. These particles accumulate in the lungs and degrade safely, indicating potential for treating pulmonary diseases effectively.

Keywords:

Discoidal polymeric particle Drug delivery system PET imaging Pulmonary disease Zr-89

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Area of Science:

Biomedical Engineering
Materials Science
Pharmacology

Background:

Particle-based drug delivery systems are crucial for treating pulmonary diseases.
Understanding particle biodistribution and elimination is key for efficacy and safety.
Micro-sized discoidal polymeric particles (DPPs) offer potential as targeted lung carriers.

Purpose of the Study:

To characterize the biological properties of micro-sized DPPs for lung-targeted drug delivery.
To evaluate the biodistribution, degradation, and safety of DPPs in vivo.
To assess DPPs as carriers for pulmonary disease therapeutics.

Main Methods:

DPPs were fabricated using a top-down approach and characterized for size and zeta potential.
DPPs were labeled with zirconium-89 (89Zr) for PET imaging and biodistribution studies.
In vivo studies involved intravenous administration to nude mice, monitoring for 7 days.

Main Results:

DPPs exhibited a hydrodynamic size of 2.8 ± 6.1 μm and zeta potential of -39.9 ± 5.39 mV.
No acute toxicity was observed at doses up to 25 mg/kg.
89Zr-labeled DPPs showed high lung accumulation and degradation within 3 days, with low bone uptake.

Conclusions:

Micro-sized DPPs are suitable for lung-targeted drug delivery.
The observed biodistribution and degradation profile supports their safety and efficacy.
DPPs represent a promising platform for developing novel pulmonary disease treatments.