Turning solid into gel for high-efficient persistent luminescence-sensitized photodynamic therapy.

Area of Science:

• Biomaterials Science
• Photodynamic Therapy
• Nanotechnology

Background:

• Persistent luminescence (PL) materials offer potential as internal light sources for photodynamic therapy (PDT).
• Existing PL materials face challenges like low utilization efficiency and signal attenuation due to corrosion and screening.
• Developing robust and efficient PL-based systems is crucial for advanced biomedical applications.

Purpose of the Study:

• To develop a novel persistent luminescence hydrogel for enhanced photodynamic therapy.
• To overcome the limitations of traditional PL materials in biological environments.
• To create a biocompatible and injectable light source for localized tumor treatment.

Main Methods:

• A "solid into gel" strategy was employed, dispersing high-temperature calcined PL material into an alginate-Ca2+ hydrogel.
• The synthesis method ensured 100% material utilization and preserved the intrinsic PL properties.
• Characterization included assessment of biocompatibility, luminescence, renewability, injectability, and tumor retention.

Main Results:

• The synthesized hydrogel exhibited excellent biocompatibility and bright, stable persistent luminescence.
• The material demonstrated red light renewability and favorable syringeability for in vivo injection.
• The hydrogel showed strong retention within tumor sites, acting as an effective localized light source.

Conclusions:

• The "solid into gel" strategy successfully fabricates a high-performance persistent luminescence hydrogel.
• This hydrogel enables 100% utilization of PL materials, offering superior performance for PDT.
• The approach holds significant promise for diverse theranostic applications, accommodating various agent types.