Related Experiment Video
Updated: Jan 22, 2026

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
Preschool Age Anthropometric Evaluation of the Nose After Bilateral Complete Cleft Lip Repair
Kengkart Winaikosol1, Jirapat Patthanapalakornskul2, Kamonwan Jenwitheesuk1
1Plastic & Reconstructive Unit, Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen.
Insights
Surgery for bilateral cleft lip in children achieved good nasal tip height, columella height, and dome height. However, nasal width and cleft lip angle require further surgical refinement for optimal aesthetic outcomes.
Area of Science:
- Plastic Surgery
- Craniofacial Surgery
- Pediatric Surgery
Background:
- Bilateral complete cleft lip presents significant aesthetic challenges, particularly affecting nasal symmetry and appearance.
- Preschool-aged children with bilateral cleft lip require surgical interventions to address these aesthetic concerns.
Purpose of the Study:
- To quantitatively assess the aesthetic outcomes of primary cheiloplasty in preschool-aged children with bilateral complete cleft lip.
- To compare key nasal aesthetic parameters between operated cleft lip patients and a control group of healthy children.
Main Methods:
- Three-dimensional (3D) photographs were used to analyze nasal aesthetic parameters in 26 preschool-aged patients with bilateral complete cleft lip and 30 controls.
- Key parameters evaluated included nasal tip height (NTH), columella height (CH), dome height (DH), nasal width (NW), and cleft lip angle (CLA).
Main Results:
- Patients with bilateral cleft lip showed comparable NTH, CH, and DH to controls.
- Significantly greater NW (P < 0.001) and altered CLA (P < 0.001) were observed in the cleft group.
- The ratio of NTH to NW also differed significantly between groups (P < 0.001).
Conclusions:
- The surgical protocol effectively addressed NTH, CH, DH, and certain width/height ratios in bilateral cleft lip repair.
- Further surgical optimization is recommended for nasal width and cleft lip angle to achieve more complete aesthetic symmetry.
Objective:
To evaluate the aesthetic outcomes of surgery in preschool-aged bilateral complete cleft lip patients by comparing their nasal aesthetic parameters with those of normal children.
Setting And Sample Population:
Twenty-six 4 to 6-year-old (preschool age) patients with bilateral complete cleft lip who underwent primary cheiloplasty and a control group of 30 children in Northeast Thailand of the same age were enrolled.
Materials And Methods:
Nasal aesthetic parameters were analyzed in terms of 3 ratios and 1 angle using three-dimensional photographs. The data from bilateral cleft lip patients were compared with those from a control group.
Results:
The nasal parameters of patients in the cleft group were the same as those in the control group in terms of nasal tip height (NTH), columella height (CH), and dome height (DH) (P values were 0.361, 0.494, and 0.086), but nasal width (NW) was greater in the cleft group (P < 0.001). The nasal aesthetic parameters differed significantly between the 2 groups in terms of CLA (P < 0.001) and ratio of NTH and NW (P < 0.001), but not in terms of the CH:NW (P = 0.190) and DH:CH ratios (P = 0.147).
Conclusion:
This treatment protocol for bilateral cleft lip was able to achieve most of the aesthetic goals in terms of NTH, CH, DH, ratio of CH to NW, and ratio of DH to CH. However, more surgical correction of NW and CLAs may be needed.
Related Concept Videos
Nose and Nasal Cavity
Mismatch Repair
Mismatch Repair
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Nucleotide Excision Repair
Overview of DNA Repair
Chemically...
Base Excision Repair
The first step of...

