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What is Variation?01:14

What is Variation?

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Apart from the measures of central tendency, distribution, outliers, and the changing characteristics of data with time, an important characteristic of any data set is its variation or spread. In some data sets, the data values are concentrated closely near the mean; in others, the data values are more widely spread out from the mean.
The range, standard deviation, standard error, and variance are the different measures of variation.
Range: The range is the difference between its maximum and...
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Variation01:19

Variation

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An important characteristic of any set of data is the variation in the data. In some data sets, the data values are concentrated closely near the mean; in other data sets, the data values are more widely spread out from the mean. The most common measure of variation, or spread, is the standard deviation, which is the square root of variance.
When independent and dependent variables are plotted on a scatter plot, the slope of a line is a value that describes the rate of change between the two...
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Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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Variation of Atmospheric Pressure01:18

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Change in atmospheric pressure with height is particularly interesting. The decrease in atmospheric pressure with increasing altitude is due to the decreasing gravitational force per unit area as we move away from the surface of the earth.
Assuming the air temperature is constant at a given altitude and that the ideal gas law of thermodynamics describes the atmosphere to a good approximation, one can find the variation of atmospheric pressure with height.
Let p(y) be the atmospheric pressure at...
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Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Updated: Jan 22, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Sino-Nasal Anatomical Variations in Rhinogenic Headache Pathogenesis.

Giacomo Sollini1, Francesco Mazzola, Andrea Iandelli

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, University of Genoa, Genova, Italy.

The Journal of Craniofacial Surgery
|July 14, 2019
PubMed
Summary

Anatomical variations in the nasal sinuses, specifically middle turbinate concha bullosa and certain frontoethmoidal cells, are significantly associated with rhinogenic headaches. These findings aid surgeons in treating this common pain syndrome.

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Area of Science:

  • Otolaryngology
  • Radiology
  • Pain Medicine

Background:

  • Rhinogenic headache (RH) is a prevalent pain syndrome with unclear origins.
  • Potential links between RH and sinonasal anatomical variations are recognized.
  • Surgical interventions for RH require a better understanding of its underlying causes.

Purpose of the Study:

  • To investigate the correlation between radiological findings and clinical symptoms in patients with rhinogenic headaches.
  • To identify specific sinonasal anatomical variations associated with RH.

Main Methods:

  • A retrospective case-control study involving 119 adults.
  • Para-nasal sinuses computed tomography (PNS-CT) scans were analyzed for anatomical variations.
  • Patients were categorized into a rhinogenic headache group (Group A) and a control group (Group B).
  • Headache symptoms were assessed using a standardized scoring system.

Main Results:

  • Middle turbinate concha bullosa (MTCB) was more prevalent in Group A (60.9%) than Group B (41.8%).
  • A statistically significant association was found between Group A and the presence of MTCB (P=0.037), Type II (P=0.016), and Type III (P=0.039) frontoethmoidal cells.
  • No significant difference in mucosal contact points or Type I/IV frontoethmoidal cells was observed between groups.

Conclusions:

  • Specific sinonasal anatomical variations, including MTCB and certain frontoethmoidal cells, are significantly associated with rhinogenic headaches.
  • These findings provide valuable insights for surgeons managing RH.
  • Further research may elucidate the precise mechanisms linking these variations to headache.