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Related Experiment Video

Updated: Jan 22, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

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Lupus: the new epidemic.

M F Ugarte-Gil1,2, L A González3, G S Alarcón4,5

  • 11 Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.

Lupus
|July 14, 2019
PubMed
Summary
This summary is machine-generated.

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Systemic Lupus International Collaborating Clinics Frailty Index predicts mortality in systemic lupus erythematosus patients: data from the Almenara Lupus Cohort.

Lupus science & medicine·2026
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Factors associated with changes in self-efficacy in patients with systemic lupus erythematosus. Data from the almenara lupus cohort.

Lupus·2026
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Increased Risk of Intrahepatic Cholestasis of Pregnancy in Women With Systemic Lupus Erythematosus Exposed to Azathioprine.

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Treatment patterns and outcomes of first lupus nephritis episode over 25 years in two Latin American cohorts.

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Lupus in Latin America: Where are we now?

Clinical rheumatology·2026
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Protective effect of antimalarials on the most frequently affected damage domains in SLE: Data from a multiethnic Latin American cohort.

Lupus·2026

Systemic lupus erythematosus (SLE) diagnosis remains challenging, hindering accurate trend analysis. Early detection and consistent criteria are crucial for understanding SLE epidemiology and improving patient outcomes.

Area of Science:

  • Rheumatology
  • Immunology
  • Epidemiology

Background:

  • Systemic lupus erythematosus (SLE) diagnosis is complex, impacting the assessment of disease trends.
  • Current classification criteria and biomarkers aid identification but early diagnosis remains difficult.
  • Defining preclinical or incomplete lupus is essential for predicting disease progression.

Purpose of the Study:

  • To review the epidemiology of SLE and its diagnostic challenges.
  • To discuss advancements in classification criteria and biomarkers for SLE.
  • To explore the concept of antinuclear antibody-negative SLE and its implications.

Main Methods:

  • Literature review of SLE classification criteria.
  • Analysis of epidemiological data and trends in SLE.
Keywords:
Systemic lupus erythematosusbiomarkersclassification criteriaepidemiologyincidencelupus incompleteprevalenceseronegative SLE

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  • Discussion of diagnostic challenges and biomarkers for early SLE detection.

    • Main Results:

    • SLE diagnosis is complicated by evolving criteria and lack of standardized definitions for early disease stages.
    • Biomarkers show promise but require further validation for routine clinical use.
    • Antinuclear antibody-negative SLE presents a unique diagnostic challenge.

    Conclusions:

    • Accurate assessment of SLE incidence and prevalence is hampered by diagnostic complexities.
    • Further research into early detection methods and standardized criteria is needed.
    • Understanding diverse SLE presentations, including ANA-negative cases, is vital for comprehensive patient care.