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Antibiotic Dereplication Using the Antibiotic Resistance Platform
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Subcutaneously administered antibiotics.

E Colin1, A Baldolli2, R Verdon2

  • 1Pharmacie centrale, CHU de Caen, avenue de la Côte-de-Nacre, 14000 Caen, France.

Medecine Et Maladies Infectieuses
|July 14, 2019
PubMed
Summary
This summary is machine-generated.

Subcutaneous antibiotic administration is common in elderly patients when intravenous therapy isn't feasible. This review found limited data, but ceftriaxone, ertapenem, and teicoplanin show promise for severe infections via this route.

Keywords:
Administration sous-cutanéeAntibioticsAntibiotiquesPharmacocinétiquePharmacokineticsSubcutaneous administrationTolerabilityTolérance

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Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Clinical Pharmacy

Background:

  • The subcutaneous route is frequently used in clinical practice, especially for elderly patients when intravenous access is challenging.
  • Limited randomized controlled trials and pharmacokinetic data exist for subcutaneous drug administration.

Purpose of the Study:

  • To review the literature on the efficacy and safety of subcutaneous antibiotic administration.
  • To identify antibiotics with adequate pharmacokinetic and pharmacodynamic profiles for subcutaneous use in severe infections.

Main Methods:

  • A comprehensive literature review was conducted.
  • Studies evaluating subcutaneous administration of antibiotics were analyzed for pharmacokinetic and pharmacodynamic data.

Main Results:

  • The review identified a significant lack of randomized studies and comprehensive pharmacokinetic data for the subcutaneous route.
  • Ceftriaxone, ertapenem, and teicoplanin were identified as antibiotics with acceptable pharmacokinetic and pharmacodynamic profiles for subcutaneous administration.
  • These antibiotics can be considered for managing severe infections when intravenous administration is not possible.

Conclusions:

  • The subcutaneous route is a viable alternative for antibiotic administration when intravenous access is not feasible, particularly in elderly patients.
  • Further research, including randomized controlled trials, is needed to strengthen the evidence base for subcutaneous antibiotic therapy.
  • Ceftriaxone, ertapenem, and teicoplanin represent suitable options for subcutaneous administration in severe infections, supported by existing data.