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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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Routine Screening Method for Microparticles in Platelet Transfusions
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Transfusing children with hemoglobinopathies.

S Allali1, M Taylor1, S Albinni2

  • 1Department of general pediatrics and pediatric infectious diseases, Paris Descartes university, Necker-Enfants malades hospital, AP-HP, 149, rue de Sèvres, 75015 Paris, France; Laboratory of excellence, GR-Ex, 75015 Paris, France; Pediatric reference center for sickle cell disease, 75015 Paris, France.

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|July 14, 2019
PubMed
Summary
This summary is machine-generated.

Thalassemia and sickle cell disease (SCD) are common inherited blood disorders. Treatment advances include stem cell transplants and promising gene therapies, shifting traditional transfusion strategies.

Keywords:
DrépanocytoseGene therapyGreffe de cellules souches hématopoïétiquesHematopoietic stem cell transplantationHydroxyureaHydroxyuréeRed blood cell transfusionSickle cell diseaseThalassemiaThalassémieThérapie géniqueTransfusion érythrocytaire

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Area of Science:

  • Hematology
  • Genetics
  • Inherited Blood Disorders

Background:

  • Thalassemia and sickle cell disease (SCD) are prevalent global inherited blood disorders.
  • Red blood cell transfusions are a primary treatment, but their use is evolving.
  • Significant advancements in treatment are emerging for both conditions.

Purpose of the Study:

  • To summarize the evolving treatment landscape for thalassemia and sickle cell disease.
  • To highlight emerging therapeutic options beyond traditional transfusion support.

Main Methods:

  • Review of current literature on thalassemia and SCD treatments.
  • Analysis of recent advancements in hematopoietic stem cell transplantation and gene therapy.

Main Results:

  • Indications for red blood cell transfusions have been refined.
  • Hematopoietic stem cell transplantation is increasingly a standard treatment option.
  • Gene therapy is demonstrating encouraging early outcomes.

Conclusions:

  • Hematopoietic stem cell transplantation is now a routine option for select patients.
  • Gene therapy offers a promising future therapeutic avenue for these inherited blood disorders.
  • The treatment paradigm for thalassemia and SCD is rapidly advancing.