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A cystic fibrosis child with lung function decline

Ersilia Vita Fiscarelli1, Gabriella Ricciotti1, Martina Rossitto1

  • 1Laboratory Department, Children's Hospital and Research Institute Bambino Gesù, Rome, Italy.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|July 14, 2019
PubMed

Insights

A rare fungal infection, Arthrographis kalrae, was identified in a child with cystic fibrosis (CF) experiencing a pulmonary exacerbation. This case highlights a previously undocumented lung infection in pediatric CF patients, emphasizing the diverse fungal biota in CF airways.

Area of Science:

  • Medical Mycology
  • Pediatric Pulmonology
  • Infectious Diseases

Background:

  • Cystic fibrosis (CF) patients face significant risks from respiratory infections, including bacterial and fungal pathogens.
  • The respiratory tract in CF is known to harbor a diverse fungal community, contributing to disease progression.

Observation:

  • A 7-year-old child with CF presented with a pulmonary exacerbation.
  • Bronchoalveolar lavage fluid analysis revealed the presence of Arthrographis kalrae.

Findings:

  • This case represents the first documented instance of Arthrographis kalrae lung infection in a pediatric patient with cystic fibrosis.
  • The isolation of A. kalrae suggests its potential role as a pathogen in CF pulmonary exacerbations.

Implications:

  • This finding expands the spectrum of fungal organisms implicated in cystic fibrosis lung disease.
  • Further research is warranted to understand the clinical significance and management of Arthrographis kalrae infections in CF patients.

Keywords:
Arthrographis kalraeBALCystic_fibrosisLung_function_declinePulmonary_exacerbation

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