Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
Understanding the Self01:28

Understanding the Self

248
The self is a central aspect of human identity, encompassing an individual’s beliefs, emotions, perceptions, and experiences. It is a cognitive and psychological construct that enables individuals to interpret their traits and behaviors, influencing how they perceive themselves and interact with the world. While personality consists of stable and enduring characteristics, the self is shaped by self-perception and social experiences. This distinction highlights the dynamic nature of the...
248
Understanding Memory01:19

Understanding Memory

1.4K
Memory is the retention of information or experiences over time, facilitated through three main processes: encoding, storage, and retrieval. Encoding is the process of inputting information into the memory system. For instance, when listening to a lecture, watching a play, reading a book, or having a conversation, the brain is actively encoding information. This initial stage involves transforming sensory input into a form that can be processed and stored by the brain. Various factors, such as...
1.4K
Understanding Love01:27

Understanding Love

182
Love, as a multifaceted psychological construct, encompasses emotions, cognitive processes, and behavioral patterns that play a crucial role in human relationships. It extends beyond attraction, manifesting in deep, enduring connections that influence personal well-being and social structures.Psychological Dimensions of LoveLove differs from friendship and mere liking through its depth and intensity. While friendship is built on mutual respect, trust, and companionship, love involves emotional...
182
Understanding Consciousness01:23

Understanding Consciousness

1.8K
Consciousness can be defined as the state of being aware of and able to think about one's existence, sensations, and surroundings. It encompasses two major components: awareness and arousal. Awareness pertains to the recognition of environmental stimuli and internal states. At the same time, arousal refers to the physiological readiness to engage with these stimuli, which varies significantly between states like sleep and wakefulness.
Sleep, a crucial state, is characterized by reduced...
1.8K
Understanding Sleep01:11

Understanding Sleep

1.4K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrative Surface Antigen Profiling of KLK2 and STEAP1 in Advanced Prostate Cancer.

Molecular cancer research : MCR·2026
Same author

NCCN Guidelines® Insights: Prostate Cancer, Version 5.2026.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

Matching Patients With Cell Surface-Targeted Clinical Trials Using Large Language Models.

JCO precision oncology·2026
Same author

Phase I multi-center clinical and biomarker study of the dual-action androgen receptor inhibitor ONCT-534.

Investigational new drugs·2026
Same author

Prostate Cancer-Associated Fibroblasts: A Review on CAF Functions, Heterogeneity, Resistance Mechanisms, and Future in a Chip.

International journal of molecular sciences·2026
Same author

Multi-Institutional Study Evaluating the Role of Early Circulating Tumor DNA Dynamics During Treatment With Immune Checkpoint Inhibitors in Patients With Advanced-Stage Melanoma.

JCO precision oncology·2026
Same journal

Does size matter? A national analysis of patterns of adjuvant immunotherapy receipt and tumor size-dependent survival in pT3N0M0 clear cell renal cell carcinoma.

Urologic oncology·2026
Same journal

Ipsilateral sampling maintains clinically significant cancer detection and reduces overdiagnosis in PI-RADS 4-5 lesions.

Urologic oncology·2026
Same journal

Testis-sparing surgery for small testicular masses: Functional and oncological outcomes.

Urologic oncology·2026
Same journal

Subcapsular versus total orchiectomy in advanced prostate cancer: A systematic review and meta-analysis of clinical and patient-reported outcomes.

Urologic oncology·2026
Same journal

Featured SUO Fellow: Soum Lokeshwar, MD MBA.

Urologic oncology·2026
Same journal

Automating standardization of prostate cancer biopsy and histopathology reports with privacy-preserving local large language models.

Urologic oncology·2026
See all related articles

Related Experiment Video

Updated: Jan 22, 2026

Extended Time-lapse Intravital Imaging of Real-time Multicellular Dynamics in the Tumor Microenvironment
08:24

Extended Time-lapse Intravital Imaging of Real-time Multicellular Dynamics in the Tumor Microenvironment

Published on: June 12, 2016

8.6K

Understanding dynamic interactions in the prostate tumor microenvironment.

Joshua M Lang1

  • 1Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI; Department of Medicine, University of Wisconsin-Madison, Madison, WI.

Urologic Oncology
|July 14, 2019
PubMed
Summary
This summary is machine-generated.

The prostate tumor microenvironment (TME) is complex and dynamic, posing challenges for cancer therapies. Understanding TME cell interactions is key to developing new treatments for prostate cancer patients.

Keywords:
BiomarkersProstate cancerTumor microenvironment

More Related Videos

In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells
11:56

In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells

Published on: May 15, 2014

9.4K
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

10.3K

Related Experiment Videos

Last Updated: Jan 22, 2026

Extended Time-lapse Intravital Imaging of Real-time Multicellular Dynamics in the Tumor Microenvironment
08:24

Extended Time-lapse Intravital Imaging of Real-time Multicellular Dynamics in the Tumor Microenvironment

Published on: June 12, 2016

8.6K
In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells
11:56

In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells

Published on: May 15, 2014

9.4K
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

10.3K

Area of Science:

  • Oncology
  • Cancer Biology
  • Immunology

Background:

  • The prostate tumor microenvironment (TME) is a complex and dynamic system.
  • Understanding the TME is crucial for developing effective prostate cancer therapies.

Purpose of the Study:

  • To explore the diverse cell types and interactions within the prostate TME.
  • To discuss how novel research findings can be translated into therapeutic strategies for prostate cancer.

Main Methods:

  • Review of current research on prostate TME composition.
  • Analysis of cellular interactions and signaling pathways within the TME.
  • Exploration of emerging therapeutic concepts targeting the TME.

Main Results:

  • Detailed examination of various cell types (e.g., immune cells, stromal cells) in the prostate TME.
  • Identification of key interactions driving tumor progression and treatment resistance.
  • Highlighting of innovative therapeutic strategies informed by TME research.

Conclusions:

  • The complexity of the prostate TME presents significant challenges for therapeutic development.
  • Leveraging insights into TME biology offers promising avenues for novel prostate cancer treatments.
  • Translating TME research into clinical benefit requires a comprehensive understanding of its dynamic nature.