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Neurodevelopment at 2 years corrected age among Vietnamese preterm infants.
Chuong Huu Thieu Do1, Alexandra Yasmin Kruse2, Bridget Wills3,4
1Neonatal Intensive Care Unit, Children's Hospital 1, Ho Chi Minh City, Vietnam.
Archives of Disease in Childhood
|July 14, 2019
Summary
Vietnamese preterm infants receiving neonatal intensive care show significant neurodevelopmental delays at two years. Higher maternal education is linked to better infant outcomes, highlighting the need for follow-up programs in low-resource settings.
Area of Science:
- Neonatal care and developmental pediatrics
- Global child health outcomes
- Neurodevelopmental research in low- and middle-income countries
Background:
- Preterm infants face elevated risks of neurodevelopmental delay.
- Long-term outcome data for preterm infants in low-income and middle-income countries are limited.
- Understanding developmental trajectories in diverse populations is crucial for targeted interventions.
Purpose of the Study:
- To assess neurodevelopment and neurological status in 2-year-old preterm infants using the Bayley Scales of Infant and Toddler Development-3rd edition (Bayley-III).
- To compare neurodevelopmental outcomes of preterm infants with healthy Vietnamese peers.
- To identify factors associated with neurodevelopmental impairment in this cohort.
Main Methods:
- A cohort study followed preterm infants discharged from a tertiary hospital's neonatal intensive care unit (NICU) in Vietnam.
- Participants included infants born before 37 weeks of gestational age.
- Neurodevelopment was evaluated using Bayley-III and neurological examinations at 2 years corrected age, with comparisons to a control group of healthy Vietnamese infants.
Main Results:
- Preterm infants (n=184) exhibited significantly lower Bayley-III scores than healthy peers in cognition, language, and motor domains (p<0.001 for cognition and language, p=0.003 for motor).
- Prevalence of neurodevelopmental impairment was 17% for cognition, 8% for language, and 4% for motor skills; 7% were diagnosed with cerebral palsy.
- Higher maternal education was positively associated with improved infant neurodevelopment (OR 0.32, 95% CI 0.11 to 0.94).
Conclusions:
- Vietnamese preterm infants requiring NICU care demonstrated poor neurodevelopment at two years of corrected age.
- Maternal education emerged as a significant factor positively influencing infant neurodevelopment.
- Implementing standardized follow-up programs for preterm infants is recommended, particularly in resource-limited settings.
Keywords:
Bayley scaleintensive carelow resource settingmiddle-income countryneurodevelopmentpreterm infantMore Related Videos
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