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Related Concept Videos

Biological Clocks and Seasonal Responses02:45

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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Related Experiment Video

Updated: Jan 22, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
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Cancer and the Circadian Clock.

Ayesha A Shafi1,2, Karen E Knudsen3,2,4,5,6

  • 1Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

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The body's internal clock, or circadian clock, influences cancer risk. Disrupting this clock can alter cell growth, death, and DNA repair, impacting cancer development and progression.

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Area of Science:

  • Chronobiology
  • Cancer Biology
  • Molecular Physiology

Background:

  • The circadian clock governs daily physiological rhythms in mammals.
  • Circadian disruption is recognized as a carcinogen and cancer risk factor.
  • Understanding the link between circadian disruption and cancer is crucial for public health.

Purpose of the Study:

  • To review the mechanisms by which circadian disruption influences cancer.
  • To highlight the role of circadian regulation in cancer hallmarks.
  • To explore potential therapeutic strategies based on circadian-cancer interactions.

Main Methods:

  • Literature review of current research on circadian rhythms and cancer.
  • Analysis of studies investigating circadian clock functions in cancer biology.
  • Synthesis of data on circadian disruption's impact on cell proliferation, apoptosis, DNA repair, and metabolism.

Main Results:

  • Circadian regulatory functions are integral to controlling cell proliferation and programmed cell death (apoptosis).
  • Circadian disruption affects DNA repair mechanisms, potentially increasing mutation rates.
  • Metabolic alterations driven by circadian dysregulation contribute to cancer development.
  • Emergent data link circadian disruption to multiple hallmarks of cancer.

Conclusions:

  • Circadian clock disruption significantly impacts cancer development and progression.
  • Targeting circadian pathways offers novel avenues for cancer prevention and treatment.
  • Further research into circadian-cancer crosstalk is essential for developing effective interventions.