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Novel bioreductive mitosene and mitosane analogues of mitomycin C
W Verboom1, D N Reinhoudt, B H Lammerink
1Laboratory of Organic Chemistry, Twente University of Technology, AE Enschede, The Netherlands.
Anti-Cancer Drug Design
|December 1, 1987
Abstract:
Mitosenes of both the pyrrolo- and pyrido[1,2-a]indole type have been prepared via a modified Madelung reaction of benzeneacetonitriles ortho-substituted with gamma- and delta-lactam moieties, respectively, followed by modification of the resulting heterotricyclic compounds. Some in vitro anti-tumour activity data of these novel compounds are rearrangement of 2-(1-pyrrolidinyl)-3-vinylquinone derivatives to 5,8-dioxo-1H-pyrrolo[1,2-a]indoles.