Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lymphocyte activation by B. subtilis spores.

S Fais1, F Pallone, C Nava

  • 1Cattedra di Gastroenterologia I, Università La Sapienza, Roma, Italy.

Bollettino Dell'Istituto Sieroterapico Milanese
|January 1, 1987
PubMed
Summary

Bacillus Subtilis spores activate lymphocytes, increasing expression of key activation markers. This immune response, particularly at higher concentrations, resembles that induced by common mitogens, suggesting T cell involvement.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Experimental Lung Transplantation Related With HIF-1, VEGF, ROS. Assessment of HIF-1alpha, VEGF, and Reactive Oxygen Species After Competitive Blockade of Chetomin for Lung Transplantation in Rats.

Physiological research·2024
Same author

Maxillofacial Injuries in Padel Game.

Journal of maxillofacial and oral surgery·2023
Same author

Hospital workers mental health during the COVID-19 pandemic: methods of data collection and characteristics of study sample in a university hospital in Milan (Italy).

BMC medical research methodology·2021
Same author

De novo truncating variants in the intronless IRF2BPL are responsible for developmental epileptic encephalopathy.

Genetics in medicine : official journal of the American College of Medical Genetics·2018
Same author

Wiedemann-Steiner syndrome as a major cause of syndromic intellectual disability: A study of 33 French cases.

Clinical genetics·2018
Same author

MED13L-related intellectual disability: involvement of missense variants and delineation of the phenotype.

Neurogenetics·2018

Area of Science:

  • Immunology
  • Microbiology

Background:

  • Bacillus Subtilis spores (BSs) are known for various biological activities.
  • The immunomodulatory effects of microbial components are of significant research interest.

Purpose of the Study:

  • To investigate the in vitro effect of Bacillus Subtilis spores on lymphocyte activation.
  • To analyze the kinetics of activation antigen expression in response to BSs.

Main Methods:

  • Peripheral mononuclear cells were cultured with varying concentrations of Bacillus Subtilis spores.
  • Expression of activation antigens MLR3, MLR4, and HLA-DR was analyzed kinetically.

Main Results:

  • Bacillus Subtilis spores induced increased expression of MLR3, MLR4, and HLA-DR markers.
  • At high concentrations, BSs demonstrated a quantitative and qualitative effect similar to mitogens PHA and ConA.

Conclusions:

  • The results suggest that Bacillus Subtilis spores can activate lymphocytes in vitro.
  • T cells are likely involved in the immune response to Bacillus Subtilis spores.

Related Experiment Videos