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Updated: Jan 22, 2026

Extended Live Imaging of Female Drosophila melanogaster Germline Stem Cell Niches
Published on: December 20, 2024
Molecular control of the female germline stem cell niche size in Drosophila
Hwei-Jan Hsu1, Majid Bahader2, Chun-Ming Lai2,3
1Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan. cohsu@gate.sinica.edu.tw.
Abstract:
Adult stem cells have a unique capacity to renew themselves and generate differentiated cells that are needed in the body. These cells are recruited and maintained by the surrounding microenvironment, known as the stem cell niche, during organ development. Thus, the stem cell niche is required for proper tissue homeostasis, and its dysregulation is associated with tumorigenesis and tissue degeneration. The identification of niche components and the mechanisms that regulate niche establishment and maintenance, however, are just beginning to be uncovered. Germline stem cells (GSCs) of the Drosophila ovary provide an excellent model for studying the stem cell niche in vivo because of their well-characterized cell biology and the availability of genetic tools. In this review, we introduce the ovarian GSC niche, and the key signaling pathways for niche precursor segregation, niche specification, and niche extracellular environment establishment and niche maintenance that are involved in regulating niche size during development and adulthood.
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