Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Scientific Laws and Theories02:31

Scientific Laws and Theories

87.5K
Scientific Laws
87.5K
The Scientific Method03:50

The Scientific Method

65.3K
Chemistry is an empirical science. Scientists often pose questions to understand the chemistry in everyday life and seek answers to these questions. To achieve this, scientists follow a definitive series of steps that together make up the Scientific Method. This approach involves making observations, asking questions, building a hypothesis, conducting experiments, analyzing results, and forming a conclusion. 
65.3K
The Scientific Method01:32

The Scientific Method

260.2K
The scientific method is a detailed, empirical problem-solving process used by biologists and other scientists. This iterative approach involves formulating a question based on observation, developing a testable potential explanation for the observation (called a hypothesis), making and testing predictions based on the hypothesis, and using the findings to create new hypotheses and predictions.
Generally, predictions are tested using carefully-designed experiments. Based on the outcome of these...
260.2K
The Scientific Method02:40

The Scientific Method

64.9K
Research is what makes the difference between facts and opinions. Facts are observable realities, and opinions are personal judgments, conclusions, or attitudes that may or may not be accurate. In the scientific community, facts can be established only using evidence collected through empirical research.
64.9K
Curing of Concrete01:20

Curing of Concrete

354
The hydration of cement takes place within the water-filled capillary pores. However, environmental elements can disrupt this process by evaporating water from the concrete surfaces. Sealed concrete with a water-cement ratio below 0.5 experiences self-desiccation, leading to water loss. The water loss in concrete is mitigated by curing. This technique involves keeping the concrete saturated to maintain the necessary temperature and moisture conditions, to optimally fill the spaces in the cement...
354
Curing Methods01:26

Curing Methods

284
Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
284

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An integrated, scaled approach to resolve TSC2 variants of uncertain significance.

Nature communications·2026
Same author

RNA targeting therapy for a prenatally enriched potassium channel associated with severe childhood epilepsy and premature death.

Nature communications·2026
Same author

Novel <i>PCDH12</i> pathogenic missense variants cause neurodevelopmental disorders with ocular malformation.

medRxiv : the preprint server for health sciences·2026
Same author

Toward a Disease-Modifying Therapy for Dravet Syndrome.

The New England journal of medicine·2026
Same author

An integrated, scaled approach to resolve TSC2 variants of uncertain significance.

bioRxiv : the preprint server for biology·2026
Same author

Efficacy of Dravet Syndrome Treatments in a Subset of Individuals with 2q24.3 Deletion: A-5 Patient Case Series.

Journal of child neurology·2026

Related Experiment Video

Updated: Jan 22, 2026

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.9K

The path from scientific discovery to cures for epilepsy.

Gemma L Carvill1, Chris G Dulla2, Dan H Lowenstein3

  • 1Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

Neuropharmacology
|July 14, 2019
PubMed
Summary

Scientists are advancing epilepsy research through genetic discoveries and big data analysis to find new cures. Future efforts require collaboration to prevent, modify, and cure epilepsy, focusing on patient needs.

Keywords:
Animal modelBig dataBiomarkerCellular modelCureDrug-screeningEpigeneticsEpilepsyEpileptogenesisGeneticsOptogenetics

More Related Videos

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring
11:28

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring

Published on: June 13, 2025

1.3K
Author Spotlight: Insights into the Techniques and Findings of Recent Advancements in Epilepsy Research
04:41

Author Spotlight: Insights into the Techniques and Findings of Recent Advancements in Epilepsy Research

Published on: October 13, 2023

2.2K

Related Experiment Videos

Last Updated: Jan 22, 2026

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.9K
Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring
11:28

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring

Published on: June 13, 2025

1.3K
Author Spotlight: Insights into the Techniques and Findings of Recent Advancements in Epilepsy Research
04:41

Author Spotlight: Insights into the Techniques and Findings of Recent Advancements in Epilepsy Research

Published on: October 13, 2023

2.2K

Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacology

Background:

  • Epilepsies are complex neurological disorders with diverse genetic and acquired causes.
  • Current understanding necessitates a multifaceted strategy for epilepsy prevention and cure.

Purpose of the Study:

  • To review scientific progress in understanding and treating epilepsies.
  • To highlight advancements in identifying genetic risk factors and utilizing big data for epilepsy research.
  • To discuss novel therapeutic approaches and future directions for epilepsy cure.

Main Methods:

  • Integration of clinical and molecular 'omics' datasets using big data approaches.
  • Utilizing various animal and cellular epilepsy models.
  • Employing cutting-edge cellular, optogenetic, chemogenetic, and anti-seizure drug screening techniques.

Main Results:

  • Identification of genetic risk factors contributing to epilepsy development.
  • Discovery of common pathophysiological signatures and biomarkers through integrated data analysis.
  • Advancements in preclinical models facilitating the testing of novel therapeutic strategies.

Conclusions:

  • Developing cures for epilepsy requires a coordinated effort between basic scientists, clinicians, and industry.
  • Future research should focus on early identification of at-risk individuals, targeting epileptogenesis, and optimizing treatments.
  • Patient-centered approaches are crucial for guiding the development and implementation of new epilepsy therapies.