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Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
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Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

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Successful treatment of kerion with itraconazole and ALA-PDT: A case report

Jiejie Lu1, Wen Li1, Wen'ai Zheng2

  • 1Department of Dermatology, the Fifth People's Hospital of Hainan Province, 33, Southern Road of Longkun, Qiongshan District, Haikou, 570206, Hainan, China.

Photodiagnosis and Photodynamic Therapy
|July 14, 2019
PubMed

Insights

Photodynamic therapy (PDT) offers a safe and effective alternative for treating kerion, a severe fungal infection of hair follicles. This approach, using ALA-PDT combined with oral antifungals, successfully treated a child with persistent symptoms.

Area of Science:

  • Dermatology
  • Mycology
  • Photomedicine

Background:

  • Kerion, a severe inflammatory fungal infection of hair follicles, presents treatment challenges, especially when oral antifungal agents show limited efficacy.
  • Photodynamic therapy (PDT) has emerged as a promising treatment modality for various fungal infections.

Observation:

  • A 9-year-old girl presented with a 2-month history of scalp erythema, pustular, and tender plaques, diagnosed as kerion based on clinical presentation and mycological evidence.
  • The patient experienced a relapse despite a 6-week course of oral itraconazole.

Findings:

  • Successful treatment was achieved using three sessions of aminolevulinic acid photodynamic therapy (ALA-PDT) in combination with oral itraconazole.
  • The combined therapy resulted in the complete resolution of the kerion symptoms.

Implications:

  • ALA-PDT represents a viable and effective alternative or adjunctive treatment for kerion.
  • This therapeutic approach demonstrates safety, minimal side effects, and good repeatability for managing challenging kerion cases.
Keywords:
Aminolevulinic acidItraconazoleKerionPhotodynamic therapy

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