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Updated: Jan 22, 2026
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ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
Published on: July 29, 2007
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Motor neuron disease with malignancy: Clinical and pathophysiological insights
Mana Higashihara1, Parvathi Menon2, Nimeshan Geevasinga2
1Department of Neurology, Westmead Hospital, Westmead, Australia.
Summary
Motor neuron disease with malignancy (MND-M) patients exhibit cortical dysfunction similar to classical motor neuron disease (MND) phenotypes. This suggests MND-M is part of the broader MND spectrum, not a distinct entity.
Area of Science:
- Neurology
- Oncology
- Neuroscience
Background:
- The association between motor neuron disease (MND) and malignancy is debated, with some viewing it as coincidental and others as a distinct clinical entity.
- Investigating the pathophysiology of MND with malignancy (MND-M) is crucial for understanding this relationship.
Purpose of the Study:
- To explore the disease pathophysiology in patients with motor neuron disease and malignancy (MND-M).
- To compare the clinical features and cortical function of MND-M patients with sporadic and familial MND cohorts.
Main Methods:
- In-depth phenotyping and cortical function assessment were performed on 13 MND-M patients.
- Results were compared against established sporadic and familial MND cohorts.
Main Results:
- MND-M patients predominantly showed a lower motor neuron phenotype.
- Upper motor neuron (UMN) scores were significantly reduced in MND-M patients compared to other MND cohorts.
- Cortical hyperexcitability was observed in MND-M patients, similar to sporadic and familial MND, despite a lack of UMN signs.
Conclusions:
- Motor neuron disease with malignancy (MND-M) appears to fall within the spectrum of motor neuron disease (MND).
- Findings support the concept of a coincidental association, with observed dysfunction explained by classical MND phenotypes.
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