Related Experiment Video
Updated: Jan 22, 2026
10:51
Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
Published on: August 30, 2016
23.4K
Dynamic gut microbiome changes following regional intestinal lymphatic obstruction in primates
F Becker1, F N E Gavins2, J Fontenot3
1Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, USA; Department for General-Visceral and Transplant Surgery, University of Münster, Münster, Germany.
Summary
This study reveals that lymphatic obstruction in a novel Crohn's Disease (CD) model significantly alters the gut microbiome. Specific bacterial groups, like Prevotellaceae, increase, potentially driving disease activity.
Area of Science:
- Gastroenterology
- Microbiology
- Immunology
Background:
- Inflammatory bowel disease (IBD) pathogenesis is linked to lymphostasis.
- The impact of lymphatic obstruction on the intestinal microbiome in Crohn's Disease (CD) remains unclear.
Purpose of the Study:
- To investigate how gut lymphatic obstruction affects the intestinal microbiome in a new CD model.
- To explore the relationship between lymphatic changes and microbial alterations in CD.
Main Methods:
- Utilized a novel African Green monkey model of CD, termed ATLAS (African green monkey truncation of lymphatics with obstruction and sclerosis).
- Analyzed the gut microbiome at 7, 21, and 61 days post-intervention in the ATLAS model compared to controls.
Main Results:
- Significant alterations in gut microbial composition were observed at 7 days post-ATLAS.
- Increased abundance of Prevotellaceae and Bacteroidetes-Prevotella-Porphyromonas (BPP) were noted.
- These microbial changes may correlate with disease activity in this CD model.
Conclusions:
- This study provides the first evidence linking structural lymphatic changes and gut functional alterations with microbiome shifts in CD pathophysiology.
- Lymphatic obstruction demonstrably impacts the gut microbiome, offering new insights into CD mechanisms.
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