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Cancer the'RBP'eutics-RNA-binding proteins as therapeutic targets for cancer
Shakur Mohibi1, Xinbin Chen1, Jin Zhang1
1Comparative Oncology Laboratory, Schools of Veterinary Medicine and Medicine, University of California at Davis, United States.
Abstract:
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics.
Insights
RNA-binding proteins (RBPs) are crucial for RNA regulation and cancer development. Targeting RBPs offers a promising therapeutic strategy for cancer treatment.
Area of Science:
- Molecular Biology
- Cancer Biology
- Biochemistry
Background:
- RNA-binding proteins (RBPs) regulate essential RNA processes like splicing, translation, and degradation.
- RBPs are increasingly recognized for their significant roles in cancer development and progression.
Purpose of the Study:
- To review current knowledge on RNA-binding proteins and their involvement in tumorigenesis.
- To explore the potential of targeting RBPs as a therapeutic strategy for cancer.
Main Methods:
- Literature review of recent studies on RBPs in cancer.
- Analysis of the functional roles of RBPs in normal cellular processes and cancer.
- Evaluation of RBP-targeting strategies for cancer therapy.
Main Results:
- RBPs are critical regulators of diverse RNA-related cellular functions.
- Dysregulation of RBPs is implicated in the initiation and metastasis of various cancers.
- Targeting specific RBPs shows potential for novel cancer treatments.
Conclusions:
- RNA-binding proteins are key players in both normal cellular functions and cancer.
- Targeting RBPs represents a promising avenue for developing innovative cancer therapeutics.