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Updated: Jan 22, 2026

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
09:03

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Published on: November 17, 2014

10.1K

Immune checkpoint inhibitor therapy in solid organ transplant recipients: A patient-centered systematic review

Juliya Fisher1, Nathalie Zeitouni2, Weijia Fan3

  • 1Department of Dermatology, Columbia University Irving Medical Center, New York, New York.

Journal of the American Academy of Dermatology
|July 15, 2019
PubMed
Abstract

Insights

Immunotherapy use in solid organ transplant recipients (SOTRs) with metastatic cancer shows significant risks of organ rejection. Despite cautious use, cancer progression remains a more frequent cause of death than graft rejection in this population.

Area of Science:

  • Oncology
  • Transplant Immunology

Background:

  • Immunotherapies have advanced cancer treatment.
  • Solid organ transplant recipients (SOTRs) are typically excluded from immunotherapy trials.
  • Limited data exists on immunotherapy safety and efficacy in SOTRs with metastatic cancers.

Purpose of the Study:

  • To systematically review the safety and efficacy of immunotherapies in SOTRs with metastatic cancers.
  • To analyze organ rejection rates and mortality causes in SOTRs receiving immunotherapy.

Main Methods:

  • Systematic review of existing literature.
  • Statistical analysis using Fisher's exact test and Kruskal-Wallis test.

Main Results:

  • 37% of SOTRs experienced organ rejection; 14% died from rejection.
  • Nivolumab had the highest rejection rate (52.2%), followed by pembrolizumab (26.7%) and ipilimumab (25%).
  • Kidney transplant recipients showed the highest rejection rates (40.1%). Cancer progression caused death in 64% of patients, with ipilimumab associated with the highest disease-related mortality (75%). Pembrolizumab demonstrated the highest overall response rate (40%).

Conclusions:

  • Physicians should exercise caution when administering immunotherapy to SOTRs.
  • While organ rejection is a concern, it is not the most common cause of death in this patient group.
  • Further research with larger sample sizes is needed to fully understand immunotherapy outcomes in SOTRs.
Keywords:
CTLA-4 inhibitorsPD-1 inhibitorsallograft rejectionimmune checkpoint inhibitorssolid organ transplant

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