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Investigation of Xenobiotics Metabolism In Salix alba Leaves via Mass Spectrometry Imaging
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Investigation of Xenobiotics Metabolism In Salix alba Leaves via Mass Spectrometry Imaging

Published on: June 15, 2020

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Precision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance

Maria Jove1, Jade Spencer2, Malcolm Clench3

  • 1Medical Oncology department, Institut Català d'Oncologia, Barcelona, Spain; Leeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds, UK.

Critical Reviews in Oncology/Hematology
|July 15, 2019
PubMed

Insights

Precision pharmacology using mass spectrometry imaging (MSI) can overcome pharmacokinetic drug resistance in cancer treatment. MSI precisely maps drug distribution in tumors, guiding optimized dosing and delivery for better therapeutic outcomes.

Area of Science:

  • Pharmacology
  • Analytical Chemistry
  • Oncology

Background:

  • Systemic cancer treatment failure is often linked to inadequate drug delivery to tumors, a phenomenon known as pharmacokinetic drug resistance.
  • Understanding drug distribution is crucial for effective cancer therapy.
  • Precision pharmacology offers advanced techniques to address these delivery challenges.

Purpose of the Study:

  • To review the application of mass spectrometry imaging (MSI) in studying cancer drug distribution.
  • To explore MSI's utility from preclinical research to clinical applications.
  • To highlight MSI's role in overcoming pharmacokinetic drug resistance.

Main Methods:

  • Mass spectrometry imaging (MSI) for visualizing drug distribution in tissues.
  • Review of preclinical studies characterizing anti-cancer drug distribution.
  • Analysis of MSI applications in optimizing drug dose, schedule, combinations, and delivery systems.
  • Examination of MSI's emerging role in clinical cancer research.

Main Results:

  • MSI enables detailed characterization of drug distribution within the body and tumor microenvironment.
  • MSI aids in defining optimal dosing strategies, drug combinations, and novel drug delivery systems.
  • MSI is increasingly valuable in translational cancer research, bridging preclinical findings to clinical settings.

Conclusions:

  • Mass spectrometry imaging is a powerful tool for precision pharmacology in oncology.
  • MSI facilitates a deeper understanding of drug pharmacokinetics and distribution in cancer.
  • The application of MSI is expanding from benchtop research to clinical practice, promising improved cancer treatment efficacy.
Keywords:
Drug developmentIntra-tumoural drug distributionMALDI-MSIPharmacokinetics

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