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What is Gene Expression?01:42

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Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells
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Morphological Characterization and Gene Expression Patterns for Melanin Pigmentation in Rex Rabbit.

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|July 15, 2019
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Melanin levels and gene expression (MITF, TYR) correlate with coat color in Rex rabbits. Black rabbits show the highest melanin and MITF expression, impacting fur color.

Keywords:
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Area of Science:

  • Zoology
  • Genetics
  • Biochemistry

Background:

  • Animal coat color is determined by melanin quantity, character, and distribution.
  • Melanin plays a crucial role in the formation of fur and skin pigmentation.

Purpose of the Study:

  • To investigate the effect of melanin on multi-colored Rex rabbit coat formation.
  • To analyze melanin content and hair follicle structure in different colored Rex rabbits.

Main Methods:

  • Hematoxylin and Eosin (H&E) staining and melanin staining were used to observe hair follicles and melanin granules.
  • Melanin content was quantified by extraction from skin tissue.
  • mRNA and protein expression of melanin-related genes (MITF, TYR) were measured using quantitative real-time PCR and Wes assay.

Main Results:

  • Melanin granules were predominantly found in the epidermis and hair follicle roots.
  • Black Rex rabbits exhibited the highest skin melanin content.
  • MITF mRNA expression was highest in black Rex rabbits and lowest in white Rex rabbits, showing a significant correlation with melanin content.

Conclusions:

  • Melanin deposition is crucial for determining coat color in fur-bearing animals.
  • Melanin-related genes, particularly MITF, play a significant role in regulating coat color variation in Rex rabbits.
  • Understanding these genetic and biochemical pathways has economic implications for the fur industry.