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Updated: Jan 22, 2026

Detection of Histone Modifications in Plant Leaves
Published on: September 23, 2011
Two new terpenoids from the leaves of callicarpa macrophylla
Do Tien Lam1,2, Vu Thi Thu Le1,3, Pham Minh Quan1,2
1Vietnam Academy of Science and Technology (VAST), Graduate University of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Abstract:
Two new terpenoids (1-2) and seven known compounds (3-9) were isolated from methanol extract of Callicarpa macrophylla leaves. Their structures were determined to be ent-7α,16β,17,18-tetrahydroxykaur-15-one (1), 3β-acetoxy-urs-12-ene-11-one-12-ol (2), ent-1β-acetoxy-7α,14β-dihydroxykaur-16-en-15-one (3), 3β-acetoxy-11α,13β-dihydroxyolean-12-one (4), β-amyrin (5), spinasterol (6), ursolic acid (7), β-sitosterol (8), and daucosterol (9) by analyses of their MS, NMR spectroscopic data and by comparison with those reported in the literature. Compounds 1 - 4, and 7 displayed potential cytotoxic activity towards HepG-2, LU-1, and MCF-7 human cancer cell lines with IC50 values ranging from 0.46 ± 0.21 to 18.14 ± 0.33 μM. Compound 6 showed IC50 values of 14.17 ± 0.21 and 5.72 ± 0.42 μM against Hep-G2 and MCF-7 cell lines, respectively.
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Leaving Groups
In general, in a nucleophilic substitution reaction, a nucleophile displaces a functional group, called the leaving group, from the substrate to give a substituted product. A leaving group departs the substrate molecule through heterolytic cleavage, taking the pair of electrons with it to become a relatively stable weak base in the form of an anion or a neutral molecule.
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