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Lycopene enriched tomato extract suppresses chemically induced skin tumorigenesis in mice

Ashwani Koul1, Mohinder Pal Bansal1, Aniqa Aniqa1

  • 1Department of Biophysics, Panjab University, Chandigarh, India.

International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition
|July 16, 2019
PubMed

Insights

Lycopene enriched tomato extract (LycT) demonstrated significant chemopreventive effects against chemically induced skin cancer in mice. LycT reduced tumor development, inhibited cell proliferation and angiogenesis, and improved intercellular communication, suggesting its potential as a skin cancer preventative agent.

Area of Science:

  • Oncology
  • Chemoprevention
  • Dermatology

Background:

  • Skin cancer is a significant global health concern.
  • Chemically induced skin cancer models are crucial for evaluating potential therapeutic agents.
  • Lycopene, a potent antioxidant found in tomatoes, has shown promise in cancer research.

Purpose of the Study:

  • To investigate the chemopreventive effects of Lycopene enriched tomato extract (LycT) on chemically induced skin cancer in mice.
  • To evaluate LycT's impact on tumor incidence, cell proliferation, angiogenesis, and intercellular communication.

Main Methods:

  • Skin tumors were induced in male Balb/c mice using 7,12-Dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanoyl phorbol-13-acetate (TPA).
  • LycT was administered orally to mice at a dose of 5 mg/kg body weight.
  • Tumor incidence, size, and volume were measured. Epidermal morphometric parameters, and mRNA/protein expression of proliferating cell nuclear antigen (PCNA), angiogenic genes, and connexins were analyzed.

Main Results:

  • LycT significantly inhibited skin tumor incidence, number, size, burden, and volume.
  • LycT reduced cell proliferation, indicated by decreased epidermal morphometric parameters and PCNA expression.
  • LycT exhibited anti-angiogenic effects by decreasing the expression of vascular endothelial growth factor, angiopoietin-2, and basic fibroblast growth factor.
  • LycT enhanced intercellular communication by increasing the expression of connexin-32 and 43.
  • Histochemical studies showed modulation of extracellular matrix components by LycT.

Conclusions:

  • Lycopene enriched tomato extract (LycT) demonstrates significant chemopreventive potential against chemically induced skin cancer.
  • LycT acts through multiple mechanisms, including inhibition of cell proliferation and angiogenesis, and improvement of intercellular communication.
  • These findings suggest LycT could be a valuable agent for skin cancer prevention.
Keywords:
Lycopenecarotenoidsskin cancer

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