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Restless REM Sleep Impedes Overnight Amygdala Adaptation.

Rick Wassing1, Oti Lakbila-Kamal2, Jennifer R Ramautar2

  • 1Department of Sleep and Cognition, Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands; Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, The University of Sydney, 431 Glebe Point Road, Sydney, NSW 2037, Australia.

Current Biology : CB
|July 16, 2019
PubMed
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Restless REM sleep disrupts overnight brain plasticity and amygdala adaptation in humans. Targeted memory reactivation can enhance sleep

Keywords:
REM sleep fragmentationamygdalamemory reactivationself-conscious emotionsspindlestransition to REM sleep

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Area of Science:

  • Neuroscience
  • Sleep Science
  • Psychiatry

Background:

  • Insufficient silencing of the locus coeruleus (LC) during REM sleep impairs brain plasticity.
  • Restless REM sleep, common in psychiatric disorders, may indicate insufficient LC silencing.
  • Overnight reorganization of limbic circuits is crucial for emotional regulation.

Purpose of the Study:

  • To investigate how REM sleep interruptions affect overnight limbic circuit reorganization in humans with varying insomnia severity.
  • To determine if restless REM sleep impedes amygdala adaptation.
  • To explore if targeted memory reactivation can modulate these sleep-dependent processes.

Main Methods:

  • Functional MRI (fMRI) to assess amygdala reactivity before and after sleep.
  • Polysomnography (EEG) to record sleep architecture and quantify REM sleep consolidation.
  • Induction of self-conscious emotion and targeted memory reactivation using olfactory cues.

Main Results:

  • Overnight decrease in amygdala reactivity correlated with consolidated REM sleep duration.
  • Restless REM sleep hindered overnight amygdala adaptation.
  • Targeted memory reactivation successfully enhanced both positive effects of consolidated REM sleep and negative effects of restless REM sleep.

Conclusions:

  • Restless REM sleep represents a maladaptive sleep pattern impacting emotional regulation.
  • Findings suggest a potential therapeutic target for mental disorders associated with restless REM sleep.
  • Sleep-dependent emotional memory consolidation is sensitive to REM sleep quality.