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[Imaging changes in brain microstructural in long-term abstinent from methamphetamine-dependence].

Lidan Fan1, Qingqing Zhang2, Shengxiang Liang3

  • 1Department of Radiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|July 16, 2019
PubMed
Summary

Long-term methamphetamine abstinence shows persistent brain microstructure changes, detectable with diffusion tensor imaging (DTI). These abnormalities in brain regions persist even after 14 months of abstinence.

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Addiction Research

Background:

  • Methamphetamine dependence is associated with significant neurobiological alterations.
  • Understanding long-term recovery and brain changes in abstinent individuals is crucial for treatment.
  • Diffusion tensor imaging (DTI) offers insights into white matter microstructure.

Purpose of the Study:

  • To investigate brain microstructure changes in individuals abstinent from methamphetamine dependence for over 14 months.
  • To explore the relationship between DTI-derived parameters and cognitive executive functions.
  • To utilize DTI to identify potential imaging biomarkers for long-term abstinence.

Main Methods:

  • Employed diffusion tensor imaging (DTI) and voxel-based analysis on 26 long-term abstinent methamphetamine users and 26 controls.
  • Assessed fractional anisotropy (FA) and mean diffusivity (MD) to detect microstructural differences.
  • Conducted Spearman correlation analysis between DTI parameters and cognitive executive function tests.

Main Results:

  • No significant differences in cognitive executive function tests were observed between groups.
  • Abstinent individuals showed decreased FA in regions including the right precuneus and superior frontal gyrus.
  • Increased MD was found in areas such as the right inferior frontal gyrus, precuneus, and middle temporal gyrus.

Conclusions:

  • Brain microstructure abnormalities, indicated by DTI parameters, persist in individuals long-term abstinent from methamphetamine dependence.
  • DTI is a valuable tool for detecting and visualizing these persistent microstructural changes.
  • Findings suggest that neurobiological recovery from methamphetamine dependence is a prolonged process.