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Related Experiment Video

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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

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Association between PDE4D polymorphism and ischemic stroke in young population.

Xuejing Yue¹, Liu Lixia¹, Haiqing Yan²

¹School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453000, China.

Saudi Journal of Biological Sciences

|July 16, 2019

Summary

Genetic variations in phosphodiesterase 4D (PDE4D) gene SNP83 are linked to ischemic stroke risk in young Chinese adults. SNP87 showed no significant association with ischemic stroke risk.

Keywords:

Gene polymorphism Ischemic stroke Phosphodiesterase 4D

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Area of Science:

Genetics
Neurology
Cardiovascular Research

Background:

Ischemic stroke (IS) poses a significant health burden, particularly in younger populations.
Genetic factors, including gene polymorphisms, are increasingly recognized as contributors to IS risk.
The phosphodiesterase 4D (PDE4D) gene is a potential candidate involved in cerebrovascular diseases.

Purpose of the Study:

To investigate the association between specific polymorphisms (SNP83 and SNP87) in the PDE4D gene and the risk of ischemic stroke.
To evaluate the role of PDE4D gene variants in the pathogenesis of IS among young Chinese individuals.

Main Methods:

A case-control study involving 393 participants, categorized into ischemic stroke (IS) and non-IS groups.
Semiconductor high-throughput sequencing was employed for genotyping.
Multivariate logistic regression analysis was utilized to assess the association between genotypes and IS risk.

Main Results:

The CC genotype and C allele frequency of the PDE4D gene SNP83 were significantly higher in the IS group compared to the control group.
No statistically significant difference in genotype frequency distribution of the PDE4D gene SNP87 was observed between the IS and non-IS groups.
These findings suggest a potential genetic predisposition to IS related to SNP83.

Conclusions:

The study identified a significant association between PDE4D gene SNP83 polymorphisms and an increased risk of ischemic stroke in the young Chinese population of northern Henan province.
No significant association was found between PDE4D gene SNP87 polymorphisms and ischemic stroke risk in this cohort.
These results highlight the potential role of specific PDE4D gene variants in the etiology of ischemic stroke in young adults.