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Comparative Study of the Use of Intra-articular and Systemic Meloxicam to Control Experimentally Induced
Valéria Trombini Vidotto1,2,3, Rodrigo Tesser da Rocha1, Caroline Lorraine de Paiva4
1Postgraduate Program on Animal Science, União Pioneira de Integração Social, Brasília, DF, Brazil.
Objective:
This study aimed to evaluate morphologic changes, as well as chondroprotective and intra-articular effects of meloxicam on joint repair in rabbits induced by experimental trochleoplasty, minimizing possible adverse side effects.
Methods:
Thirty-five rabbits were divided into four groups: the control group, which did not undergo surgery, and operated groups, which used different ways of administering the anti-inflammatory agent: systemic, 0.2 mg/kg; intra-articular, 0.5 mg/kg; positive group control, without meloxicam. Each operated group was divided according to the periods of 7 or 30 days evaluation after surgery.
Results:
Regarding macroscopic and histological evaluation of cartilage, after 30 days, most animals showed almost complete joint repair, the presence of few or no inflammatory cells; whereas part of the animals treated with meloxicam presented necrosis in the trochlear ridge and absence of inflammatory cells after 7 days. In positive control group, it was observed moderate inflammation and connective tissue proliferation. None of the animals in the operated groups showed irregularities 30 days after surgery.
Conclusion:
Either intra-articular or systemic, meloxicam revealed to be favorable to be used for joint repair and control of inflammatory reaction.
Insights
Meloxicam administration, both systemic and intra-articular, promotes favorable joint repair and controls inflammation following trochleoplasty in rabbits. This anti-inflammatory agent aids in cartilage regeneration and reduces inflammatory cell presence post-surgery.
Area of Science:
- Orthopedic Surgery
- Pharmacology
- Regenerative Medicine
Background:
- Experimental trochleoplasty in rabbits can induce joint damage and inflammation.
- Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) with potential chondroprotective properties.
- Evaluating meloxicam's effects on joint repair and inflammation is crucial for optimizing post-surgical outcomes.
Purpose of the Study:
- To assess the morphologic changes and chondroprotective effects of meloxicam on joint repair after experimental trochleoplasty in rabbits.
- To evaluate the intra-articular and systemic administration of meloxicam for joint repair.
- To minimize potential adverse side effects of meloxicam during joint healing.
Main Methods:
- Thirty-five rabbits were divided into control and operated groups.
- Operated groups received meloxicam systemically (0.2 mg/kg) or intra-articularly (0.5 mg/kg).
- Evaluations of macroscopic and histological cartilage changes were performed at 7 and 30 days post-surgery.
Main Results:
- After 30 days, most animals exhibited near-complete joint repair with minimal inflammatory cells.
- Some meloxicam-treated animals showed trochlear ridge necrosis and absent inflammatory cells at 7 days.
- The positive control group (no meloxicam) displayed moderate inflammation and connective tissue proliferation.
Conclusions:
- Meloxicam, administered systemically or intra-articularly, is beneficial for joint repair.
- Meloxicam effectively controls the inflammatory response in experimental trochleoplasty.
- The study supports the use of meloxicam for enhancing joint healing and managing inflammation post-surgery.
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