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Related Experiment Videos

Polyglactin 910/polydioxanone bicomponent totally resorbable vascular prostheses.

H P Greisler1, E D Endean, J J Klosak

  • 1Loyola University Medical Center, Department of Surgery, Maywood, IL 60153.

Journal of Vascular Surgery
|May 1, 1988
PubMed
Summary
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Bicomponent bioresorbable vascular prostheses using polyglactin 910 and polydioxanone showed excellent patency and resistance to dilatation in rabbit aortas. These novel prostheses offer a promising solution for vascular repair, integrating well with host tissues.

Area of Science:

  • Biomaterials Science
  • Vascular Surgery
  • Regenerative Medicine

Background:

  • Bioresorbable vascular prostheses made from lactide-glycolide copolymers are replaced by host tissues.
  • Prosthetic resorption rate influences tissue replacement kinetics.
  • Need for enhanced resistance to dilatation during resorption period.

Purpose of the Study:

  • Evaluate bicomponent resorbable prostheses for augmented resistance to dilatation.
  • Assess efficacy during the resorption of rapidly resorbed components.

Main Methods:

  • Constructed bicomponent prostheses from polyglactin 910 (PG910) and polydioxanone (PDS).
  • Implanted prostheses into rabbit infrarenal aortas (n=37).
  • Harvested specimens for microscopy and assessed patency, aneurysms, stenosis, and capsule thickness.

Related Experiment Videos

  • Perfused explants to measure prostacyclin metabolite (6-keto-PGF1 alpha) levels.

    • Main Results:

    • Achieved 100% patency with no aneurysms and only 3% stenosis.
    • PG910 resorbed by 2 months; PDS resorbed by 6 months.
    • Inner capsule thickness at 1 month (303 ± 30 microns) was intermediate between 100% PDS and 100% PG910 prostheses.
    • Capsule thickness stabilized similarly across groups (417-502 microns).

    Conclusions:

    • Bicomponent prostheses demonstrate high patency and mechanical integrity during resorption.
    • The combination of PG910 and PDS provides a balanced resorption profile.
    • These prostheses represent a viable option for vascular repair, promoting tissue integration.