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Apatinib, combined with chemotherapy or alone is effective in treating angiosarcoma: a case report

Mingyang Liu1, Yongmin Liu1, Huannan Guo1

  • 1Department of Oncology, General Hospital of Heilongjiang Province Land Reclamation Bureau, Harbin.

Anti-Cancer Drugs
|July 16, 2019
PubMed

Insights

A patient with metastatic skin angiosarcoma resistant to chemotherapy and pazopanib showed significant tumor shrinkage with apatinib treatment. This suggests apatinib

Area of Science:

  • Oncology
  • Medical Genetics

Background:

  • Angiosarcomas are rare, aggressive vascular tumors with poor prognoses.
  • Current treatment options are limited, and targeted therapies like vascular endothelial growth factor receptor inhibitors are under investigation.

Observation:

  • A patient with metastatic skin angiosarcoma exhibited resistance to multi-line chemotherapy and pazopanib.
  • Remarkable lesion shrinkage was observed following treatment with apatinib, alone or in combination with chemotherapy.

Findings:

  • The patient's primary lesion, harboring KRAS V14I and RBM10 E119D mutations, had a shorter progression-free survival (10 months) compared to brain metastases without these mutations (≥12 months).
  • This case highlights a potential differential response to apatinib based on mutational status.

Implications:

  • Apatinib shows promise as a treatment for advanced angiosarcomas, particularly in cases resistant to standard therapies.
  • Further research is warranted to elucidate the role of KRAS and RBM10 mutations in predicting apatinib efficacy in angiosarcoma.
  • This study provides valuable insights for future clinical trials and therapeutic strategies for angiosarcoma.

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