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Updated: Jan 22, 2026
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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
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Frailty in medically complex individuals with chronic HIV
Susan Morgello1,2, Gary Gensler3, Seth Sherman3
1Department of Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, New York.
AIDS (London, England)
|July 16, 2019
Summary
In aging individuals with HIV, symptomatic cognitive impairment, depression, diabetes, and COPD increase frailty risk. Men are less likely to be frail than women.
Area of Science:
- Gerontology
- Infectious Diseases
- Neuroscience
Background:
- Aging with HIV is associated with multimorbidity and frailty.
- However, not all individuals with medical conditions develop frailty.
- Identifying factors contributing to frailty in this population is crucial.
Purpose of the Study:
- To identify factors associated with frailty in a cohort of HIV-infected individuals with multimorbidity.
- To explore the relationship between medical comorbidities, immunologic/virologic parameters, and neuropsychiatric variables with frailty.
Main Methods:
- Analysis of a prospective, observational, longitudinal cohort of 332 participants.
- Frailty status was assessed using the Fried Frailty Index (categorized as frail, prefrail, or robust).
- Logistic regression analyses (univariate and multivariable) were performed to identify predictors of frailty.
Main Results:
- Twenty-two percent of participants were classified as frail.
- Significant predictors of frailty included symptomatic cognitive impairment, depressive symptoms, diabetes mellitus, and chronic obstructive pulmonary disease (COPD).
- Men were less likely to be frail compared to women.
Conclusions:
- Symptomatic neuropsychiatric illness significantly increases the odds of frailty in HIV-infected individuals.
- The association between frailty and symptomatic impairment highlights the role of functional limitations.
- Understanding these associations is vital for managing HIV-associated morbidity in aging populations.
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