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Factors affecting the occurrence of gastrointestinal bleeding in acute ischemic stroke patients

Jia Fu1

  • 1Department of Neurology, Chifeng Municipal Hospital, Inner Mongolia, China.

Medicine
|July 16, 2019
PubMed

Insights

Gastrointestinal bleeding (GIB) after acute cerebral infarction is linked to increased mortality. Key risk factors include advanced age, low Glasgow Coma Scale score, infection, high NIHSS score, and posterior circulation infarction.

Area of Science:

  • Neurology
  • Gastroenterology
  • Clinical Medicine

Background:

  • Gastrointestinal bleeding (GIB) is a frequent complication following stroke.
  • GIB can adversely impact patient prognosis and outcomes.

Purpose of the Study:

  • To identify risk factors for GIB in patients with acute cerebral infarction.
  • To investigate the association between GIB and 1-year mortality in these patients.

Main Methods:

  • A retrospective analysis of 1662 acute cerebral infarction patients (2015-2016).
  • 1:1 matched case-control study with conditional logistic regression.
  • Multivariate logistic regression and stepwise conditional regression analyses were employed.

Main Results:

  • Independent risk factors for GIB included advanced age, low Glasgow Coma Scale (GSC) score, infection, high NIHSS score, and posterior circulation infarction.
  • GIB was significantly associated with higher 1-year mortality and disability (mRS grade ≥ 4).
  • Independent predictors of 1-year mortality were GIB, infection, high mRS grade, and coronary heart disease.

Conclusions:

  • GIB is a common complication in acute cerebral infarction patients.
  • Identifying specific risk factors can aid in early GIB risk assessment.
  • GIB presence correlates with increased 1-year mortality and poorer functional outcomes post-stroke.

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