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Acute pulmonary thromboembolism caused by factor V Leiden mutation in South Korea: A case report

Hun Jee Choe¹, Koung Jin Suh¹, Ji Yun Lee¹

¹Department of Internal Medicine, Seoul National University, Seoul National University Bundang Hospital, Seongnam.

|July 16, 2019

Abstract

Rationale:

Although Factor V Leiden (FVL) mutation is a major cause of inherited thrombophilia in Western populations; the mutation is extremely rare in Asia.

Patient Concerns:

Here we report a case of a 28-year old Korean woman admitted to our hospital with extensive pulmonary embolism.

Diagnosis:

She was heterozygous for FVL mutation up on evaluation, and screening for asymptomatic family members also revealed heterozygous FVL mutation for her mother.

Interventions:

Enoxaparin 1 mg/kg was initiated, followed by rivaroxaban 15 mg every 12 hours.

Outcomes:

The patient showed improvement in both subjective dyspnea and right ventricular dysfunction and was successfully discharged after five hospital days.

Lessons:

FVL mutation screening may be considered in Asian patients with thrombophilia of uncertain etiology in the future.

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