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Premalignant Clonal Hematopoietic Proliferations.

Valentina Nardi1,2, Frank C Kuo3, Robert P Hasserjian1,2

  • 1Department of Pathology, Massachusetts General Hospital, Boston.

American Journal of Clinical Pathology
|July 16, 2019
PubMed
Summary
This summary is machine-generated.

This workshop reviewed premalignant clonal hematopoietic proliferations, including monoclonal gammopathy of uncertain significance and clonal hematopoiesis of indeterminate potential. Consensus diagnoses were rendered for 27 cases, aiding in understanding these conditions.

Keywords:
CCUSCHIPClonal hematopoiesisIn situ follicular neoplasiaMGUSMonoclonal B-cell lymphocytosis

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Area of Science:

  • Hematopathology
  • Hematology
  • Oncology

Background:

  • Advances in immunophenotyping and genetic studies increasingly detect small clonal populations in asymptomatic individuals.
  • These findings represent premalignant clonal hematopoietic proliferations of myeloid and lymphoid lineages.
  • Conditions include monoclonal gammopathy of uncertain significance, monoclonal B-cell lymphocytosis, and clonal hematopoiesis of indeterminate potential.

Purpose of the Study:

  • To review and discuss premalignant clonal hematopoietic proliferations.
  • To establish consensus diagnoses for challenging cases.
  • To evaluate current diagnostic criteria for these conditions.

Main Methods:

  • A panel reviewed 27 cases of clonal proliferations of indeterminate significance or potential.
  • Cases included both myeloid (18) and lymphoid (9) types.
  • Consensus diagnoses were established based on provided case data.

Main Results:

  • The workshop successfully rendered consensus diagnoses for the reviewed cases.
  • Key premalignant conditions discussed include monoclonal gammopathy of uncertain significance, monoclonal B-cell lymphocytosis, in situ follicular neoplasia, in situ mantle cell neoplasia, clonal hematopoiesis of indeterminate potential, and clonal cytopenia of undetermined significance.
  • The incidental detection of these clonal populations in asymptomatic individuals was highlighted.

Conclusions:

  • Current diagnostic criteria for premalignant clonal hematopoietic proliferations were reviewed and discussed.
  • The workshop provided valuable insights into the diagnosis and management of these evolving entities.
  • Understanding these conditions is crucial for accurate prognostication and patient care.