Increased frequency of HLA-A*02 in patients with atherosclerosis is associated with VZV seropositivity

HLA molecules are inherited key molecules in the immune inflammation and specific responses to environmental pathogens. We investigated the association of HLA-A alleles with Varicella zoster virus (VZV) seropositivity in patients with atherosclerosis (AS).

Plasma Anti-VZV IgG and molecular HLA type were detected in 203 (100 AS⁺ and 103 AS^-) individuals.

Of 100 AS⁺ individuals, 66 were anti-VZV⁺ and 34 were anti-VZV^-. Of 103 age/sex-matched AS^- individuals, 59 were anti-VZV⁺ and 44 were anti-VZV^-. Anti-VZV-IgG in AS⁺ cases was higher than AS^- controls (p = .034). The mean anti-VZV IgG in HLA-A*02⁺AS⁺ individuals was higher than HLA-A*02⁺AS^- controls (p < .001). HLA-A*02 was associated with VZV-seropositivity (p = .01) in AS⁺ patients. A higher frequency of HLA-A*02-allele in AS⁺ patients compared to AS^- controls (p = .015) and an accumulation of HLA-A*02-allele in AS⁺ anti-VZV⁺ group (33.3%, p = .004) was observed.

HLA-A alleles and immune responses to VZV are associated with clinical atherosclerosis.