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Synthesis and in-vivo taste assessment of meloxicam pivalate

Bandoo C Chatale1, Mariam S Degani1

  • 1Department of Pharmaceutical Sciences & Technology, Institute of Chemical Technology , Mumbai , India.

Drug Development and Industrial Pharmacy
|July 16, 2019
PubMed

Insights

Meloxicam pivalate (MXP) was synthesized to mask the bitter taste of meloxicam (MX), a common arthritis medication. Taste tests in rats showed MXP significantly improved palatability compared to MX.

Area of Science:

  • Pharmaceutical Chemistry
  • Drug Development
  • Sensory Science

Background:

  • Meloxicam (MX) is a widely prescribed nonsteroidal anti-inflammatory drug for arthritis.
  • A significant drawback of meloxicam is its pronounced bitter taste, limiting patient compliance.
  • Prodrug strategies are employed to improve drug palatability and delivery.

Purpose of the Study:

  • To synthesize a prodrug of meloxicam to improve its taste profile.
  • To evaluate the palatability of the novel meloxicam prodrug in a preclinical model.

Main Methods:

  • Chemical synthesis of meloxicam pivalate (MXP) from meloxicam.
  • Taste evaluation using a single bottle-test rat model.
  • Comparative palatability assessment between MXP and MX solutions.

Main Results:

  • Successful synthesis of meloxicam pivalate (MXP).
  • The rat model demonstrated a significant improvement in the palatability of MXP compared to MX.
  • The chemical modification effectively masked the bitter taste of the parent drug.

Conclusions:

  • Meloxicam pivalate (MXP) represents a promising strategy to overcome the bitter taste of meloxicam.
  • This prodrug approach could enhance patient adherence to meloxicam therapy.
  • Further investigation into MXP for clinical use is warranted.
Keywords:
Meloxicam (MX)and taste assessmentmeloxicam pivalate (MXP)prodrugrat model

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