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On-Chip Endothelial Inflammatory Phenotyping
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Atherosclerosis, inflammatory factor changes, cognitive disorder and vascular endothelial functions in patients with

Lirong Lin1, Yaxuan Zhang2, Qingxin Zeng1

  • 1Department of Neurology, Inner Mongolia Baogang Hospital, Baotou, Inner Mongolia, China.

Clinical Hemorheology and Microcirculation
|July 16, 2019
PubMed

Insights

Leukoaraiosis (LA) is linked to increased atherosclerosis, inflammation, and impaired cognitive and vascular functions. Higher LA grades correlate with worse outcomes, highlighting its systemic impact.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Geriatrics

Background:

  • Leukoaraiosis (LA) is a common finding in elderly individuals and patients with cerebrovascular disease.
  • LA is associated with an increased risk of cognitive impairment and stroke.
  • The underlying mechanisms linking LA to these outcomes are not fully understood.

Purpose of the Study:

  • To investigate the relationship between leukoaraiosis (LA) severity and atherosclerosis (AS).
  • To assess inflammatory factor levels, cognitive function, and vascular endothelial function in patients with varying grades of LA.
  • To explore the correlation between LA grades and cognitive disorders.

Main Methods:

  • 180 cerebral infarction patients were categorized into four LA grades.
  • Atherosclerosis was assessed using Doppler ultrasound and MRI.
  • Inflammatory markers (CRP, MMP-9), cognitive function (MMSE), and endothelial function (MDA, SOD, ET, NO) were measured.

Main Results:

  • AS incidence and inflammatory factor levels increased with LA grade.
  • Patients with higher LA grades showed lower MMSE scores and reduced SOD/NO levels.
  • Elevated MDA, ET, CRP, and MMP-9 were observed in more severe LA cases.

Conclusions:

  • Leukoaraiosis is associated with increased systemic inflammation.
  • LA is implicated in cognitive dysfunction and impaired vascular endothelial function.
  • These findings suggest LA as a potential marker for cerebrovascular disease progression.
Abstract

Keywords:
Leukoaraiosisatherosclerosiscognitive functioninflammatory factorsvascular endothelial functions

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