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Related Experiment Video

Updated: Jan 22, 2026

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Tryptase values in anaphylaxis and insect allergy.

Patrizia Bonadonna^1,2, Luigi Scaffidi^3,2, Elisa Boni⁴

¹Allergy Unit.

Current Opinion in Allergy and Clinical Immunology

|July 16, 2019

Summary

Serum tryptase measurement aids in diagnosing allergic diseases and mast cell disorders. Elevated tryptase levels help identify mast cell activation, guiding treatment for anaphylaxis and venom allergies.

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Area of Science:

Immunology
Allergology
Hematology

Background:

Mast cells play a crucial role in allergic reactions and mast cell disorders.
Tryptase is a key enzyme released by mast cells.
Understanding mast cell activation is vital for diagnosing and managing allergic diseases.

Purpose of the Study:

To highlight the diagnostic utility of serum tryptase measurement.
To review the role of tryptase in allergic diseases and mast cell disorders.
To understand the implications of tryptase levels in anaphylaxis and venom allergy.

Main Methods:

Review of recent data on mast cells and tryptase.
Analysis of tryptase levels in the context of allergic reactions.
Correlation of tryptase levels with mast cell activation and specific disorders.

Main Results:

Transiently elevated tryptase levels post-reaction indicate mast cell activation.
Serum tryptase is associated with Hymenoptera venom allergy and mastocytosis.
Baseline tryptase levels support diagnosis and guide treatment decisions for anaphylaxis and mast cell disorders.

Conclusions:

Serum tryptase is a valuable diagnostic tool for allergic diseases and mast cell disorders.
Tryptase measurement aids in elucidating reaction mechanisms and identifying mast cell activation.
Baseline tryptase levels are critical for determining treatment strategies, including venom immunotherapy and lifelong management.